日期 : 10月 27日星期二
時間 : 上午11:00
地點 : 國衛院竹南院區/ 行政大樓B1第4會議室
主題 : The Role of TDP-43 in the Pathogenesis of Frontotemporal Lobar Degeneration
講師 : Kuen-Jer James Tsai (蔡坤哲), Ph.D.
Frontotemporal lobar degeneration (FTLD) is one of the most common neurodegenerative diseases, especially in the dementia. TDP-43 is a multifunctional DNA/RNA-binding factor, which has been identified as the major disease protein of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 has been known mainly as a nuclear protein, with two RNA-recognition motifs (RRM), RRM1 and RRM2, and a glycine-rich region in its C-terminus. However, the role of TDP-43 in the pathogenesis of FTLD-U has remained unknown. Therefore, to know how TDP-43 pathology results in neuronal death in FTLD-U may provide a potential therapeutic strategy to FTLD-U. In our study, to test whether aberrant cell cycle activity and DNA damage involve in the neuronal death results from TDP pathology, the expression level of cell cycle associated genes and DNA damage marker had been examined. Form the result, cell cycle re-expression and DNA damage occur in the TDP-43 disease animal model and human brain tissues.