Feng-Shiun Shie

Selective Publications


  1. US patent (2021): Anti-Abeta antibodies and uses thereof (US 11,084,873B2;專利權期間: 2021/5/30-2039/6/2)
  2. US Provisional patent (2021): Combined therapy for treating Alzheimer’s disease (63/177,213).
  3. 中華民國專利 (2021):「抗-乙型澱粉樣蛋白抗體及其用途」(專利證號:發明第I721440號; 專利權期間: 2021/3/11-2039/5/29)
  4. 專利合作條約PCT申請(2020): Anti-Abeta antibodies and uses thereof (PCT Patent Application No. PCT/US19/34259)。
  5. US Provisional patent 2018: Anti-Aβ antibodies, compositions, methods and uses (62/678,080).
  6. 中華民國專利:「治療阿茲海默症或帕金森氏症之醫藥組成物」(專利證號 I 450716 Sep 1, 2014)。
  7. Novel neuro-protective compounds for neurodegenerative diseases. (US 8,198,284 B2 Jun 12, 2012).


  1. Hsu JTA, Tien CF, Yu GY, Shen S, Lee YH, Hsu PC, Wang Y, Chao PK, Tsay HJ and Shie FS*. The effects of Aβ1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2. International Journal of Molecular Sciences. 2021, IF= 923, Journal Ranking: 67/297 (22.5%), Biochemistry & Molecular Biology.
  2. Lin CH, Tao PL, Tsay HJ, Chiang YC, Chang WT, Ho IK, and Shie FS*. Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine. Behavioural Neurology. 2021, Article ID 6301458. IF=342, Journal Ranking: 26/60 (43%), Psychology.
  3. Yeh SH, Shie FS (co-first author), Liu HK, Yao HH, Kao PC, Lee YH, Chen LM, Hsu SM, Chao LJ, Wu KW, Shiao YJ, Tsay HJ. A high-sucrose diet aggravates Alzheimer’s disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice. Neurobiol Aging. 2020 Jun;90:60-74. IF=4.347, Journal Ranking: 10/51 (19.6%), Geriatrics & Gerontology.
  4. Kuo YM, Hsu PC, Hung CC, Hu YY, Huang YJ, Gan YL, Lin CH, Shie FS, Chang WK, Kao LS, Tsou MY, Lee YH. Soluble epoxide hydrolase inhibition attenuates excitotoxicity involving 14,15-epoxyeicosatrienoic acid–mediated astrocytic 7 survival and plasticity to preserve glutamate homeostasis. Neurobiol. 2019 Dec;56(12):8451-8474. IF=5.590, Journal Ranking: 61/273 (22.3%), Neurosciences.
  5. Hung CC, Lee YH, Kuo YM, Hsu PC, Tsay HJ, Hsu YT, Lee CC, Liang JJ, Shie FS.* (2019). Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity. J. Neuroinflamm. 16(1):123.
  6. Lee YH, Hsu HC, Kao PC, Shiao YJ, Yeh HH, Shie FS, Hsu SM, Yeh CW, Liu HK, SB Yang *, Tsay HJ.* (2018). Augmented insulin and leptin resistance of high fat diet-fed APPswe/PS1dE9 transgenic mice exacerbate obesity and glycemic dysregulation. Int. J. Mol. Sci. 19(8). pii: E2333.
  7. Yeh CW, Liu HK, Lin LC, Liou KT, Huang YC, Lin CH, Tzeng TT, Shie FS*, Tsay HJ*, Shiao YJ.* (2017). Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice. J. Ethnopharm. 209:50-61. 
  8. Wu SN*, Chern JH, Shen S, Chen HH, Hsu YT, Lee CC, Chan MH, Lai MC, Shie FS.* (2017). Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels. J Cell Physiol. 232(12):3409-3421.
  9. Tsay HJ, Huang YC, Chen YJ, Lee YH, Hsu SM, Tsai KC, Yang CN, Huang FL, Shie FS, Lee LC, Shiao YJ (2016). Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. J Biomed Sci. 23(1):27.
  10. Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, Lin TN, Shie FS, Kao LS, Chou CM, Lee YH*. (2016). Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity. J Neurosci. 36(6):2027-43. 
  11. Shie FS, Shiao YJ, Yeh CW, Lin CH, Tzeng TT, Hsu HC, Huang FL, Tsay HJ, Liu HK*. (2015). Obesity and hepatic steatosis are associated with elevated serum amyloid beta in metabolically stressed APPswe/PS1dE9 mice. PLoS One. 10(8): e0134531. 
  12. Yeh CW, Yeh SHH,Shie FS, Lai WS, Liu HK, Tzeng TT, Tsay HJ*, Shiao YJ*. (2015). Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiol. Aging. 36(11):2984-2994. 
  13. Lee YH*, Lin CH, Hsu PC, Sun YY, Huang YJ, Zhuo JH, Wang CY, Gan YL, Hung CC, Kuan CY, Shie FS*. (2015). Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia. Glia. 63(7):1138-1154.
  14. Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Liu CY, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan CY. (2014). Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J. Neurosci. 34(49):16467-81.

Last Update: 2021-09-13


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