Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
Development of a novel anti-oligomeric Ab antibody for Alzheimer’s disease therapy
Synergistic effects of combining the curcumin analogue TML-6 and low-dose anti-amyloid-β antibody in APP/PS1 mice
The development of in vitro and in vivo early diagnosis of dementia
Dr. Wen-Hai Chou
Neutralization of lipocalin-2 diminishes stroke-reperfusion injury
Genetic inhibition of PKCε attenuates neurodegeneration after global cerebral ischemia in male mice
PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration
Lipocalin-2 mediates the rejection of neural transplants
Dr. Seong-Jin Yu
Neuroprotection against acute stroke or TBI (neuroprotection induced by human milk oligosaccharide after acute ischemic stroke; neuroprotection induced by human milk oligosaccharide against acute hemorrhage stroke; neuroprotection induced by a novel anti-inflammatory agent CX807 for acute hemorrhage stroke; neuroprotection through anti-inflammation through repositioning naltrexone after acute TBI; neuroprotection through repositioning acetyl cholinerestase inhibitor phenserine after acute ischemic stroke injury)
Experimental therapy for subacute and chronic stroke (Post-treatment with 2’-FL for the subacute/chronic stroke; stem cell therapy for subacute/chronic stroke)
Collaborative research in PD (stem cell therapy for PD; pharmacological therapy for PD; antibody therapy for PD)
Psychiatric and Addiction Group
Dr. Wei J. Chen
Blood-based biomarkers as diagnostics or theranostics for schizophrenia: a multi-omics approach (polygenic risk score and symptomatology, severity, and response to antipsychotics during first- episode psychosis; DNA methylation in peripheral blood cells is correlated with symptomatology, severity, and response to antipsychotics during first- episode psychosis; blood-based expression levels of miRNAs and symptomatology, severity, and response to antipsychotics during first-episode psychosis; and whether a combination of schizophrenia PRS, DNA methylation, and miRNAs improve the diagnostic discrimination as well as the prediction of treatment response)
Psychotic Inpatients Cohort in Taiwan (PICT) (to recruit a total of 1000 cases of eligible psychotic inpatients from psychiatric departments in various hospitals by the end of the four-year study)
Dr. Hwei-Hsien Chen
Development of novel medicine for club drug–induced psychological dependence, psychiatric disorders and neurodegeneration
he neurobiology of ketamine reinforcement
Developing NMDA receptor modulators for treatment of ketamine addiction and related cognitive deficits
Dr. Yu-Li Liu
Methadone dosage regulatory mechanism search
Neurotoxicity of ketamine abuse
Stroke-induced neurodegenerative disease, particularly post stroke dementia
Dr. Sheng-Chang Wang
Clinical features of community drug users in Taiwan (suicidality among community ketamine ever users in Taiwan; sleep quality and internet use among community ketamine users; neurobiological and neurocognitive biomarkers of drug use disorders; pharmacogenomics of methadone treatment for heroin dependence)
Using big data analytics in drug use problems in Taiwan (outcomes of heroin users with experience of methadone maintenance treatment)
Development of the evidence-based addiction treatment models (developing the culturally-adapted models for addiction treatment in Taiwan; implementing the evidence-based addiction treatment programs)
Translational research projects on addiction treatment practice and policy (improving quality of services for methadone clinics- promoting methadone guest-dosing, point-of-care urine drug testing and suicide prevention; and enquiring the addiction treatment system in the Ministry of Justice-affiliated detention centers)
Dr. Yen-Feng Lin
Methamphetamine use disorder (prognosis-associated factors of coerced addiction treatment for methamphetamine users; a genome-wide polygenic approach to methamphetamine use and methamphetamine-induced psychosis: genetic etiology, cross-trait polygenic overlap, and potential causal relationships)
Phenome-wide genome-wide analysis of complex phenotypes in Taiwanese population
Dr. Chuan-Yu Chen
Children of addicted parents: unmet needs in healthcare and social services (ended at the end of 2020),
Scheduled III and IV drugs-involved young people: unmet needs in health and social car (2021/01-), which will be described below in terms of rationales and methodology.
Dr. Tsuo-Hung Lan
Taiwan health insurance claim data analysis
Neurodegenerative disorder in elderly
Smoking cessation program in women and elderly
Training Office for Addiction Treatment Professionals
Dr. Wei J. Chen
Fostering addiction treatment and intervention professionals:
translating “Universal Treatment Curriculum (UTC) for Substance Use Disorders” into Chinese and to establish localized Taiwanese version of the training materials;
providing needed training for non-physician primary workers in addiction treatment and intervention in different stages;
advocating “Clinical and Research Dual Fellowship in Addiction”
Neurodegeneration Group 
Psychiatric and Addiction Group
Training Office for Addiction Treatment Professionals