2022 神醫中心學術演講 7 (現場+視訊)
日期 : 7月 26日星期二
時間 : 上午11:00
地點 : 國衛院竹南院區/ 行政大樓B1第6會議室
主題 : 非侵入性腦刺激之神經調控技術方法以及其神經疾病之潛在應用／Non-invasive brain stimulation approaches for neuromodulation: methods and potential applications in neurological disorders
講師 : 謝宗勳 長庚大學物理治療學系暨復健科學研究所教授
報名連結
| 視訊系統 Webex : 會議連結 密碼: 1234 |
摘要
Various transcranial brain stimulation techniques such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS),cortical electricalstimulation (CES) or transcranial focused ultrasound (tFUS) have been increasingly developed for neuromodulation,which is considered to havetherapeutic potentials in neurological and neuropsychological disorders.However, the therapeutic valuesand detailed mechanisms of such brain stimulation approaches are not fully understood.For translational medical research, a suitable animal model could be the best way to provide a stable condition for identifying the mechanical insights which can help explore an effective therapeutic strategy using such brain stimulation protocols.Here, various forms of brain stimulationmethodsusingTMS, tDCS,CES, and tFUSon the cortex in rats for neuromodulation were developed. Analogous to those observed in humans, we found that thelong-term potentiation (LTP) and long-term depression (LTD)-like plasticity induced by individual TMS, tDCS, CES and tFUS protocolsin rats.Furthermore, we also identified the therapeutic effects of such interventionsin Parkinson’s disease (PD),traumatic brain injury (TBI) or epilepsy rat model. We found that long-term TMS, tDCS or CES intervention significantlyameliorated the lesion or injury-induced motor and non-motor deficits in PD or TBI rats.For tFUS, we found that tFUSeffectively suppresses acute epileptic neuron activity in anacute epilepsy ratmodel.Our studiesprovideda step toward extending human brain stimulation protocols to translational research. Thesenewly developed transcranial brain stimulation animal modelswould be useful for further identifyingthe mechanical insights and may serve as a translational platform bridging human and animal studies for establishing noveltherapeutic strategies forsuch transcranial brain stimulation protocols in neurological disorders.
會後合照
更新 : 2022-07-23
