2021 神醫中心學術演講 (現場+視訊)
日期 : 10月 26日星期二
時間 : 上午11:00
地點 : 國衛院竹南院區/ 行政大樓B1第6會議室
主題 : Epoxyeicosatrienoic acids and soluble epoxide hydrolase in physiology and diseases of the central nervous system
講師 : 李怡萱 國立陽明交通大學陽明校區教務長/生理學科暨研究所特聘教授
|視訊系統 Webex : 會議連結|
Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 (CYP450) epoxygenases from arachidonic acid. The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that serves as a key regulator of tissue EETs levels. EETs act through several signaling pathways to mediate various beneficial effects, including antiinflammation,anti-apoptosis, and anti-oxidation with relieve of endoplasmic reticulum stress, thereby sEH has become a potential therapeutic target in cardiovascular disease and cancer therapy. Enzymes for EET biosynthesis and metabolism are widely detected in both neuron and glial cells in the central nervous system (CNS). Recent studies discovered that astrocyte-derived EETs not only mediate neurovascular coupling and neuronal excitability by maintaining glutamate homeostasis, but also glia-dependent neuroprotection. Genetic ablation as well as pharmacologic inhibition of sEH have greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models. The mechanism of action of EETs in mediating astrocytic plasticity via mGluR5 signaling to maintain glutamate homeostasis under excitotoxicity, and its implication in epilepsy and neurodegenerative diseases will be discussed.