【學術演講】Small fiber neuropathy : from neurodegeneration to pain

2021 神醫中心學術演講 (視訊) 

日期 : 6月 22日星期二 

時間 : 上午11:00  

主題 : Small fiber neuropathy : from neurodegeneration to pain

講師 : 謝松蒼教授/醫師

台大醫學院解剖暨細胞生物學教授/ 台大醫院神經部主治醫師


視訊系統 Webex  : 會議連結

會議號:184 776 0653

密碼:1234


摘要

Small fibers in the skin are responsible for pain and thermal sensations. These fibers are frequently degeneration in diabetes and chemotherapy-induced peripheral neuropathy. Usually they can only be examined with electron microscopy. We developed small punch skin biopsy as a novel diagnostic approach which is now accepted by the neurology field as the standard for small fiber neuropathy. Patients with small fiber neuropathy also suffer from neuropathic pain. Traditionally peripheral sensitization accounts for the mechanisms of neuropathic pain in small fiber neuropathy. With the application of functional MRI, we demonstrated maladaptive brain plasticity underlying neuropathic pain after small fiber nerve degeneration. A challenge in the management of small fiber neuropathy is the exploration of underlying etiology beyond common diabetes and chemotherapy etc. We identified hereditary transthyretin (TTR) amyloidosis (hATTR) as the most frequency cause of “idiopathic” neuropathy. With a unique mutation of TTR A97S, we further generated knock-in mice to investigate the mechanisms of neurodegeneration of hATTR.

2021-6-9

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