日期 : 1月 26日星期二
時間 : 上午11:00
地點 : 國衛院竹南院區/ 行政大樓B1第4會議室
主題 : Brain structural and functional change under chronic ketamine exposure
Ketamine has recently been approved to treat patients with refractory depression.
However, recreational use of ketamine is rapidly becoming a serious public health issue in East and Southeast Asia. Previous studies of prolonged ketamine exposure on brain is relative scarce at present.
Thirty-six ketamine users and 39 healthy subjects were recruited. We conducted brain MRI with cognitive measures on chronic ketamine users. Besides on the clinical profiles of chronic ketamine users, we also explore their cognitive characteristics including depression, impulsivity and short-term memory. Further, we divided ketamine users into adolescent- and adult-onset group to see the early exposure effect.
These results characterized the effects of chronic ketamine use on brain structure and function. First, resting functional connectivity of the subgenual anterior cingulate cortex was associated with depression in chronic ketamine users, with sex differences in these changes; Further, altered striatal connectivity was illustrated in chronic ketamine users, and the potential role of putamen OFC connectivity in supporting the correlation between impulsivity and duration of ketamine use. Besides, the influence of earlier exposure of ketamine on the development of the brain was demonstrated. The precuneus, a structure of central importance to cerebral functional organization, may be particularly vulnerable to the influences of early ketamine exposure. How these structural and functional brain changes may relate to the cognitive and affective deficits remains to be determined with further studies.