Feng-Shiun Shie


Selective Publications

Patents:

  1. 正式專利申請(2019): ANTI-Abeta ANTIBODIES AND USES THEREOF。申請國包括:中華民國(108008733)、美國(16/426,585)、與專利合作條約PCT (PCT/US19/34259)。
  2. 美國暫時專利(Provisional patent 2018): Anti-Aβ antibodies, compositions, methods and uses (62/678,080)。
  3. 中華民國專利:「治療阿茲海默症或帕金森氏症之醫藥組成物」(專利證號 I 450716 Sep 1, 2014)。
  4. Novel neuro-protective compounds for neurodegenerative diseases. (US 8,198,284 B2 Jun 12, 2012).

Papers:

  1. Kuo YM, Hsu PC, Hung CC, Hu YY, Huang YJ, Gan YL, Lin CH, Shie FS, Chang WK, Kao LS, Tsou MY, Lee YH.* (2019). Soluble epoxide hydrolase inhibition attenuates excitotoxicity 6 involving 14,15-epoxyeicosatrienoic acid–mediated astrocytic 7 survival and plasticity to preserve glutamate homeostasis. Mol. Neurobiol. (accepted).
  2. Hung CC, Lee YH, Kuo YM, Hsu PC, Tsay HJ, Hsu YT, Lee CC, Liang JJ, Shie FS.* (2019). Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity. J. Neuroinflamm. 16(1):123.
  3. Lee YH, Hsu HC, Kao PC, Shiao YJ, Yeh HH, Shie FS, Hsu SM, Yeh CW, Liu HK, SB Yang *, Tsay HJ.* (2018). Augmented insulin and leptin resistance of high fat diet-fed APPswe/PS1dE9 transgenic mice exacerbate obesity and glycemic dysregulation. Int. J. Mol. Sci. 19(8). pii: E2333.
  4. Yeh CW, Liu HK, Lin LC, Liou KT, Huang YC, Lin CH, Tzeng TT, Shie FS*, Tsay HJ*, Shiao YJ.* (2017). Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice. J. Ethnopharm. 209:50-61. 
  5. Wu SN*, Chern JH, Shen S, Chen HH, Hsu YT, Lee CC, Chan MH, Lai MC, Shie FS.* (2017). Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels. J Cell Physiol. 232(12):3409-3421.
  6. Tsay HJ, Huang YC, Chen YJ, Lee YH, Hsu SM, Tsai KC, Yang CN, Huang FL, Shie FS, Lee LC, Shiao YJ (2016). Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. J Biomed Sci. 23(1):27.
  7. Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, Lin TN, Shie FS, Kao LS, Chou CM, Lee YH*. (2016). Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity. J Neurosci. 36(6):2027-43. 
  8. Shie FS, Shiao YJ, Yeh CW, Lin CH, Tzeng TT, Hsu HC, Huang FL, Tsay HJ, Liu HK*. (2015). Obesity and hepatic steatosis are associated with elevated serum amyloid beta in metabolically stressed APPswe/PS1dE9 mice. PLoS One. 10(8): e0134531. 
  9. Yeh CW, Yeh SHH,Shie FS, Lai WS, Liu HK, Tzeng TT, Tsay HJ*, Shiao YJ*. (2015). Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiol. Aging. 36(11):2984-2994. 
  10. Lee YH*, Lin CH, Hsu PC, Sun YY, Huang YJ, Zhuo JH, Wang CY, Gan YL, Hung CC, Kuan CY, Shie FS*. (2015). Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia. Glia. 63(7):1138-1154.
  11. Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Liu CY, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan CY. (2014). Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J. Neurosci. 34(49):16467-81.

Last Update: 2018-06-26

Comments are closed.